Groundbreaking Model Reveals New Insights about Psilocybin’s Effect on the Brain

In an effort to explore the effect of psilocybin on the healthy brain, an international team of scientists created a biophysically realistic whole-brain model, described by the researchers as a “technical tour de force.” The researchers reported on this model in a paper published in the Proceedings of the National Academy of Sciences.

The groundbreaking model enabled them to observe how psilocybin impacts the activity of neurons and neurotransmitters. “Longer term, this could provide a better understanding of why psilocybin is showing considerable promise as a therapeutic intervention for neuropsychiatric disorders including depression, anxiety, and addiction,” they wrote in the paper.

Psilocybin and other psychedelics are known to affect the neurotransmitter balance of serotonin receptors in the brain, but up to this point “little has been known of this process,” write two of the paper’s authors, Morten L. Kringelbach and Gustavo Deco, in an email to Lucid News. The model they created sheds new light on these dynamics. “Using this model will be crucial for truly understanding how psilocybin can rebalance neuropsychiatric disorders such as treatment-resistant depression and addiction,” the researchers added.

Read the rest via link below…

Source: Groundbreaking Model Reveals New Insights about Psilocybin’s Effect on the Brain – Lucid News

America’s Radical History Revealed – Part One

orange-sunshine

This post is the first in a series called “America’s Radical History Revealed”, which will highlight radical reformers, rebels and non-conformists of every stripe… holy men and hell raisers, saints and sinners; I cast no judgements. People such as these have changed the world and always have. I celebrate their passion and dedication to setting minds and souls free. You can and should decide for yourself.

The following is a short excerpt from an article called, “Retracing the Steps of Psychedelic Outlaws on an LSD Mission From God”, written by  and published by KQED public media in Northern California…

It sounds like the plot to a Paul Thomas Anderson movie: a cult of Southern California surfers worships LSD as a deity in the early ’60s, becoming so obsessed with spreading psychedelics to the masses that they move their families in together and form a church.

Church members engineer an international smuggling ring to bring hash, pot, and acid back from sources in Europe and Afghanistan. They trick out their vans and surfboards with secret compartments to hide the contraband from border agents. They launder their money through an art gallery in Laguna Beach, build an LSD lab in Palm Springs, and are ultimately responsible for distributing over 100 million hits of acid.

What’s being described here is no fiction. It’s the very real — and very colorful — story of The Brotherhood of Eternal Love, the subject of Orange Sunshine, an excellent new documentary by director William A. Kirkley.